When you run, you move along quickly, and for a long time if you're running a marathon. You can also run a campaign or a business — you make them function.
There are plenty of meanings for run. If you're plotting your escape from the Tower of London, you can "make a run for it," and if you're a baseball player, you're a hero if you make a home run. When your play opens on Broadway, you hope it will have many performances — "a long run" — and if you're lucky, the New York Times will run a rave review.