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  1. enterovirus
    any of a group of picornaviruses that infect the gastrointestinal tract and can spread to other areas (especially the nervous system)
    Other possible but unproven
    viral causes include enteroviruses, human herpesvirus 6, and human T-cell lymphotropic
    virus.
  2. autoantibody
    an antibody acting against tissues of the organism that produces it
    Some patients have
    abnormal IgG, with circulating autoantibodies and immune complexes.
  3. IgG
    one of the five major classes of immunoglobulins
    Various immunologic abnormalities have been reported;
    they include low levels of IgG, decreased lymphocytic proliferation, low interferon-γ levels in
    response to mitogens, and poor cytotoxicity of natural killer cells.
  4. mitogen
    an agent that triggers mitosis
    Various immunologic abnormalities have been reported;
    they include low levels of IgG, decreased lymphocytic proliferation, low interferon-γ levels in
    response to mitogens, and poor cytotoxicity of natural killer cells.
  5. neuroendocrine
    of or relating to the nervous and endocrine systems
    Additionally, no consistent or readily reproducible
    pattern of immunologic abnormalities has been identified.Other proposed mechanisms include
    neuroendocrine abnormalities, abnormal levels of neurotransmitters, inadequate cerebral
    circulation, and elevated levels of ACE.Data indicate that relatives of patients with CFS have
    an increased risk of developing the syndrome, suggesting a familial or genetic component.
  6. reactivity
    responsive to stimulation
    Allergic reactions have also been proposed; about 65% of patients report previous
    allergies, and the rate of cutaneous reactivity to inhalants or foods is 25 to 50% higher in this
    group than in the general population.
  7. Epstein-Barr virus
    the herpes virus that causes infectious mononucleosis
    Epstein-Barr virus has also been proposed as a cause, but immunologic
    markers of exposure do not appear to be sensitive or specific.
  8. killer cell
    T cell with CD8 receptor that recognizes antigens on the surface of a virus-infected cell and binds to the infected cell and kill it
    Various immunologic abnormalities have been reported;
    they include low levels of IgG, decreased lymphocytic proliferation, low interferon-γ levels in
    response to mitogens, and poor cytotoxicity of natural killer cells.
  9. inhalant
    something that is inhaled
    Allergic reactions have also been proposed; about 65% of patients report previous
    allergies, and the rate of cutaneous reactivity to inhalants or foods is 25 to 50% higher in this
    group than in the general population.
  10. etiology
    the cause of a disease
    Etiology and Pathophysiology
    Etiology is controversial, and the precise cause remains unknown.
  11. mononucleosis
    an acute disease characterized by fever and swollen lymph nodes and an abnormal increase of mononuclear leucocytes or monocytes in the bloodstream; not highly contagious; some believe it can be transmitted by kissing
    A chronic viral infection has been
    proposed as a cause because many patients relate onset of CFS to an event similar to influenza
    or mononucleosis.
  12. abnormality
    an abnormal physical condition resulting from defective genes or developmental deficiencies
    Various immunologic abnormalities have been reported;
    they include low levels of IgG, decreased lymphocytic proliferation, low interferon-γ levels in
    response to mitogens, and poor cytotoxicity of natural killer cells.
  13. syndrome
    a pattern of symptoms indicative of some disease
    Chronic Fatigue Syndrome
    Chronic fatigue syndrome is defined as long-standing, severe, disabling fatigue without
    demonstrable muscle weakness.
  14. viral infection
    infection by a virus that is pathogenic to humans
    A chronic viral infection has been
    proposed as a cause because many patients relate onset of CFS to an event similar to influenza
    or mononucleosis.
  15. viral
    relating to or caused by a virus
    A chronic viral infection has been
    proposed as a cause because many patients relate onset of CFS to an event similar to influenza
    or mononucleosis.
  16. neurotransmitter
    a neurochemical that transmits nerve impulses across a synapse
    Additionally, no consistent or readily reproducible
    pattern of immunologic abnormalities has been identified.Other proposed mechanisms include
    neuroendocrine abnormalities, abnormal levels of neurotransmitters, inadequate cerebral
    circulation, and elevated levels of ACE.Data indicate that relatives of patients with CFS have
    an increased risk of developing the syndrome, suggesting a familial or genetic component.
  17. ACE
    proteolytic enzyme that converts angiotensin I into angiotensin II
    Additionally, no consistent or readily reproducible
    pattern of immunologic abnormalities has been identified.Other proposed mechanisms include
    neuroendocrine abnormalities, abnormal levels of neurotransmitters, inadequate cerebral
    circulation, and elevated levels of ACE.Data indicate that relatives of patients with CFS have
    an increased risk of developing the syndrome, suggesting a familial or genetic component.
  18. interferon
    an antiviral protein produced by cells that have been invaded by a virus; inhibits replication of the virus
    Various immunologic abnormalities have been reported;
    they include low levels of IgG, decreased lymphocytic proliferation, low interferon-γ levels in
    response to mitogens, and poor cytotoxicity of natural killer cells.
  19. chronic
    long-lasting or characterized by long suffering
    Chronic Fatigue Syndrome
    Chronic fatigue syndrome is defined as long-standing, severe, disabling fatigue without
    demonstrable muscle weakness.
  20. antidepressant
    a drug used to treat feelings of being extremely unhappy
    Treatment
    is rest and psychologic support, often including antidepressants.
  21. allergic
    characterized by an immune response to a food or substance
    Allergic reactions have also been proposed; about 65% of patients report previous
    allergies, and the rate of cutaneous reactivity to inhalants or foods is 25 to 50% higher in this
    group than in the general population.
  22. cutaneous
    relating to, existing on, or affecting the skin
    Allergic reactions have also been proposed; about 65% of patients report previous
    allergies, and the rate of cutaneous reactivity to inhalants or foods is 25 to 50% higher in this
    group than in the general population.
  23. diagnostic
    concerned with identifying the nature or cause of something
    Prevalence may vary because of differences in
    diagnostic evaluation, physician-patient attitudes, social acceptability, risk of exposure to an
    infectious or toxic agent, or definition and case finding.
  24. allergy
    hypersensitive immunological reaction to some substance
    Allergic reactions have also been proposed; about 65% of patients report previous
    allergies, and the rate of cutaneous reactivity to inhalants or foods is 25 to 50% higher in this
    group than in the general population.
  25. proliferation
    a rapid increase in number
    Various immunologic abnormalities have been reported;
    they include low levels of IgG, decreased lymphocytic proliferation, low interferon-γ levels in
    response to mitogens, and poor cytotoxicity of natural killer cells.
  26. influenza
    an acute febrile highly contagious viral disease
    A chronic viral infection has been
    proposed as a cause because many patients relate onset of CFS to an event similar to influenza
    or mononucleosis.
  27. virus
    infectious agent that replicates itself within living hosts
    Epstein-Barr virus has also been proposed as a cause, but immunologic
    markers of exposure do not appear to be sensitive or specific.
  28. toxic
    of or relating to or caused by a poison
    Prevalence may vary because of differences in
    diagnostic evaluation, physician-patient attitudes, social acceptability, risk of exposure to an
    infectious or toxic agent, or definition and case finding.
  29. cerebral
    of or relating to the brain
    Additionally, no consistent or readily reproducible
    pattern of immunologic abnormalities has been identified.Other proposed mechanisms include
    neuroendocrine abnormalities, abnormal levels of neurotransmitters, inadequate cerebral
    circulation, and elevated levels of ACE.Data indicate that relatives of patients with CFS have
    an increased risk of developing the syndrome, suggesting a familial or genetic component.
  30. infectious
    relating to the invasion of germs that cause disease
    Prevalence may vary because of differences in
    diagnostic evaluation, physician-patient attitudes, social acceptability, risk of exposure to an
    infectious or toxic agent, or definition and case finding.
  31. elevate
    raise from a lower to a higher position
    Additionally, no consistent or readily reproducible
    pattern of immunologic abnormalities has been identified.Other proposed mechanisms include
    neuroendocrine abnormalities, abnormal levels of neurotransmitters, inadequate cerebral
    circulation, and elevated levels of ACE.Data indicate that relatives of patients with CFS have
    an increased risk of developing the syndrome, suggesting a familial or genetic component.
  32. immune
    of the condition in which an organism can resist disease
    Some patients have
    abnormal IgG, with circulating autoantibodies and immune complexes.
  33. genetic
    relating to the study of heredity and variation in organisms
    Additionally, no consistent or readily reproducible
    pattern of immunologic abnormalities has been identified.Other proposed mechanisms include
    neuroendocrine abnormalities, abnormal levels of neurotransmitters, inadequate cerebral
    circulation, and elevated levels of ACE.Data indicate that relatives of patients with CFS have
    an increased risk of developing the syndrome, suggesting a familial or genetic component.
  34. diagnosis
    identifying the nature or cause of some phenomenon
    Depression, anxiety, and other psychologic diagnoses are typically absent.
  35. disorder
    a condition in which things are not in their expected places
    Underlying disorders that could explain the fatigue are
    absent.
  36. component
    one of the individual parts making up a larger entity
    Additionally, no consistent or readily reproducible
    pattern of immunologic abnormalities has been identified.Other proposed mechanisms include
    neuroendocrine abnormalities, abnormal levels of neurotransmitters, inadequate cerebral
    circulation, and elevated levels of ACE.Data indicate that relatives of patients with CFS have
    an increased risk of developing the syndrome, suggesting a familial or genetic component.
  37. mechanism
    device consisting of a piece of machinery
    Additionally, no consistent or readily reproducible
    pattern of immunologic abnormalities has been identified.Other proposed mechanisms include
    neuroendocrine abnormalities, abnormal levels of neurotransmitters, inadequate cerebral
    circulation, and elevated levels of ACE.Data indicate that relatives of patients with CFS have
    an increased risk of developing the syndrome, suggesting a familial or genetic component.
  38. cell
    the basic structural and functional unit of all organisms
    Other possible but unproven
    viral causes include enteroviruses, human herpesvirus 6, and human T-cell lymphotropic
    virus.
  39. data
    a collection of facts from which conclusions may be drawn
    Additionally, no consistent or readily reproducible
    pattern of immunologic abnormalities has been identified.Other proposed mechanisms include
    neuroendocrine abnormalities, abnormal levels of neurotransmitters, inadequate cerebral
    circulation, and elevated levels of ACE.Data indicate that relatives of patients with CFS have
    an increased risk of developing the syndrome, suggesting a familial or genetic component.
  40. reaction
    an idea evoked by some experience
    Allergic reactions have also been proposed; about 65% of patients report previous
    allergies, and the rate of cutaneous reactivity to inhalants or foods is 25 to 50% higher in this
    group than in the general population.
  41. physician
    a licensed medical practitioner
    Prevalence may vary because of differences in
    diagnostic evaluation, physician-patient attitudes, social acceptability, risk of exposure to an
    infectious or toxic agent, or definition and case finding.
  42. human
    a person; a hominid with a large brain and articulate speech
    Other possible but unproven
    viral causes include enteroviruses, human herpesvirus 6, and human T-cell lymphotropic
    virus.
Created on Sun Feb 27 05:33:47 EST 2011

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