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give trouble or pain to
cause to be constipated
fag, fag out, fatigue, jade, outwear, tire, tire out, wear, wear down, wear out, wear upon, weary
exhaust or get tired through overuse or great strain or stress
cause injuries or bodily harm to
ail, pain, trouble
cause bodily suffering to and make sick or indisposed
not be very easily digestible
beat, exhaust, tucker, tucker out, wash up
wear out completely
overfatigue, overtire, overweary