Rough means harsh and uneven. If you want to go driving in the rough terrain of rocky dirt roads, you'll need four-wheel drive and a stomach for bouncing.
Rough means coarse or bumpy, and can be used in many different ways. A few days after you shave, your skin will be rough with stubble. Rough seas are choppy and turbulent, and might make you seasick. On a rough day, lots of things go wrong. A rough person (who could be called "a rough") tends to get into fights. Someone raised on a farm in the mountains could be described as having a rough and rugged life.