A disruption is a major disturbance, something that changes your plans or interrupts some event or process. A screaming child on an airplane can be a disruption of the passengers' sleep.
A break in the action, especially an unplanned and confusing one, is a disruption. A sudden thunderstorm is an unwelcome disruption of an outdoor wedding ceremony, and a flat tire on an elaborate float will probably cause a parade disruption. When you disrupt something, you upset it or mess it up. In Latin disrupt means "broken into pieces," from dis, "apart," and rumpere, "to break."