Botheration is a state of annoyance or worry. It can also be a source of worry or irritation.
Lots of things in life are annoying, troubling, or worrisome: in other words, life is full of botheration. This folksy word can apply to anything that bugs you, like getting up early or stubbing your toe. When things are bothering you, you're in a state of botheration, which is like irritation or vexation. One form of botheration usually leads to the other: the more botherations (annoyances) in your life, the greater your botheration (state of annoyance).