For something that's very harmful, especially a tumor that's cancerous, use the term malignant.
Malignant and its opposite benign are medical terms used to describe a tumor or growth as either cancerous or not respectively. The gn part of both words comes from the Latin word for born, but the word root mal means "evil," while bene means "kind." A malignant tumor grows uncontrollably and spreads to other parts of the body. Less commonly, malignant can also be used to mean "evil or malicious," like when someone has a malignant imagination.