The adverb irrespective means regardless or in spite, and it is almost always followed by the word "of." Irrespective of your desire to stay inside on a bitterly cold day, the dog still needs to be walked.

Irrespective is a combination of the Latin roots ir, meaning not, and respectivus, meaning having regard for. The word irrespective is sometimes confused with its synonym regardless, giving rise in the early 20th century to the nonstandard word irregardless, which is considered an error by most grammarians, irrespective of how many people use irregardless in their everyday speech.

Definitions of irrespective
  1. adverb
    in spite of everything; without regard to drawbacks
Word Family