To hypothesize means simply to make a hypothesis. Which is just a scientific way of saying "make a really good educated guess."

Ok, so when someone hypothesizes there's a little bit more involved than just guesswork. It involves using your past knowledge and available facts to try and predict what might happen. Scientists hypothesize all the time — it's the basis for every experiment. For example, doctors examining a werewolf might hypothesize that his furry face and oddball behavior stem from an illness and not the full moon.

Definitions of hypothesize

v to believe especially on uncertain or tentative grounds

conjecture, hypothecate, hypothesise, speculate, suppose, theorise, theorize
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construct, reconstruct, retrace
reassemble mentally
develop, explicate, formulate
elaborate, as of theories and hypotheses
etymologise, etymologize
construct the history of words
develop and work out fully in one's mind
redevelop, reformulate
formulate or develop again, of an improved theory or hypothesis
Type of:
anticipate, expect
regard something as probable or likely

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