Destruction is damage so bad, things must be replaced, not fixed. Tornadoes often leave a trail of destruction, damaging neighborhoods and knocking down houses.
The Latin word destructionem, "a pulling down," is the root of destruction. When destruction strikes, things do get pulled down — from houses in the case of natural disasters or a big display of canned soups in the case of a careless shopper. Sometimes, destruction refers to death, as when critics of war talk about the resulting destruction of human life.