If the mere thought of a burrito with sour cream in it turns your stomach, you could say that you despise sour cream. You loathe it, abhor it, hate it, and think it's vile.
Despise dates all the way back to the Latin word despicare, which combines de "down" with specere "to look at." So if you look down your nose at something, you could say you despise it. Nowadays the word gets used a lot to describe things people really, really dislike, too. Note how similar in meaning and spelling despise is to Sylvester the cartoon cat's old favorite catchphrase despicable. Despicable means something worth of being despised.