When something stultifies you, it drains you of your energy, enthusiasm, or pleasure. A well-acted Shakespeare play can be a thrill. A poorly acted one can stultify like nothing else.
The verb stultify is sometimes used in place of "bore" or "exhaust," but only if something is so boring or exhausting that it makes you feel as though you might just die. It's a very negative word. If you're in a relationship that's stultifying, you should find a way out. Relationships should make you feel more alive, not less. Constant construction noise can have a stultifying effect, leaving a person almost unable to function.