Your sister is your female sibling. If your parents have six children, and all of them are girls, that means you have five sisters.
Your biological sister has the same mother and father that you have, but some sisters are adopted, or even have a different mom or dad (some people call this a stepsister or a half-sister). If you join a college sorority or a trade union, you'll refer to the other members as your sisters. Catholic nuns and other religious women are also called sisters. The roots of sister go back to words meaning "one's own" and "woman."