To frazzle is to tire or wear someone out. Traffic jams and looming deadlines tend to frazzle people.
Frazzle is a funny-looking word, but it means something not-so-funny: being exhausted, physically or mentally. Parents are frazzled by their children crying and running around. A difficult job like serving as a police officer is extremely frazzling. Doing anything that takes a mental, emotional, or physical toll is frazzling. When someone feels tired, they will often say "I'm frazzled!"