Dispirited means being down in the dumps or depressed. Losing his girlfriend and job on the same day could make someone dispirited — feeling gloomy and absolutely miserable.

You could describe people who are dispirited as having no "spirit." Whether they've broken up with someone they loved or failed to get a promotion they've been working hard to earn, they feel sad, blue, and lack any sort of enthusiasm.

Definitions of dispirited
  1. adjective
    marked by low spirits; showing no enthusiasm
    “a dispirited and divided Party”
    synonyms: listless
    lacking ardor or vigor or energy
  2. adjective
    filled with melancholy and despondency
    “a dispirited and resigned expression on her face”
    synonyms: blue, depressed, down, down in the mouth, downcast, downhearted, gloomy, grim, low, low-spirited
    affected or marked by low spirits
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