Disorienting things make you feel confused. It's disorienting each time you step out of a subway station in a big city — it takes a minute to get your bearings and figure out which direction to walk.
Waking up from the anesthetic after having your wisdom teeth removed is very disorienting, and a disorienting first day at a new school shouldn't be surprising. The adjective disorienting comes from disorient, or "make someone lose their sense of direction," which has a French source, désorienter, "to cause to lose one's bearings," or literally, "to turn from the east."