Destitution is an unfortunate state in which a person lacks something important — like money, food, companionship, or even hope.
Everyone is down on their luck sometimes. Most people will get seriously sick at some point, lose a job, or have a marriage fall apart. However, most people won't fall into destitution, which is a truly hopeless state. Homeless people are in a state of destitution. People starving or without medical care are in a state of destitution. If someone is in a state of destitution, he is experiencing utter despair.