To cancel means to call off or postpone indefinitely. Which is probably what you would do if the hotel you were planning to stay in has an infestation of bedbugs.
Scrub, scratch, or strike down — those are all other ways of saying cancel. People often cancel plans, deciding not to do something they had already scheduled. In math, if the numerator and a denominator of a fraction have common factors you can cancel the factors out, which means delete them. To cancel a debt means to get rid of it. A cancel on a postage stamp is the mark that shows it has been used.