tachycardia
abnormally rapid heartbeat (over 100 beats per minute)
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardia nSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
arrhythmia
an abnormal rate of muscle contractions in the heart
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmia nElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
phenotype
what an organism looks like as a consequence of the interaction of its genotype and the environment
NOTES:
Spontaneous germ line mutations (sporadic de novo)nnFamilial mutationsnConfer – udelit…these mutations confer a leaky phenotype on the channelnAberrantnnVELMI DOLEZITE – relationship between leak and arrhythmia – how?
cardiac arrhythmia
an abnormal rate of muscle contractions in the heart
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmia nElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
mutagenesis
an event capable of causing a mutation
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezacgytitel...
heterozygous
having dissimilar alleles at corresponding chromosomal loci
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygous nIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
hypoxia
oxygen deficiency causing a very strong drive to correct the deficiency
NOTES:
Exportnut zotero databazu na Amitov notebook!nnhypoxia nnparasympathetic versus sympathetic tone?
ectopic
exhibiting ectopia
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopic nRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
parasympathetic
of or relating to the parasympathetic nervous system
NOTES:
Exportnut zotero databazu na Amitov notebook!nnhypoxiannparasympathetic versus sympathetic tone?
SIDS
sudden and unexpected death of an apparently healthy infant during sleep
NOTES:
Increased incidence of SIDS in mutant mice might be caused by cardiac arrhythmias that are induced under conditions of catecholaminergic stress.
catecholamine
any of a group of chemicals including epinephrine and norepinephrine that are produced in the medulla of the adrenal gland
NOTES:
Confounding effectsnSusceptibilitynnArrhythmias in mice and patience with genetic mutations in RyR2 are almost always triggered by stress or catecholamines .
medicolegal
pertaining to legal aspects of the practice of medicine (as malpractice or patient consent for operations or patient information)
NOTES:
Ak ostane cas – co presne je PCR?, denaturing high performance liquid chromatographynnPreco 2. mutacia ma take iste mnozstvo cal2? (aktivita je vyssia aj bez PKA)nMissense mutationnMedicolegal nZistit ake su statistiky teraz (SIDS – 1/1000?)
chromatography
a process used for separating mixtures by virtue of differences in absorbency
NOTES:
Ak ostane cas – co presne je PCR?, denaturing high performance liquid chromatography nnPreco 2. mutacia ma take iste mnozstvo cal2? (aktivita je vyssia aj bez PKA)nMissense mutationnMedicolegalnZistit ake su statistiky teraz (SIDS – 1/1000?)
denature
modify (as a native protein) especially by heat, acid, alkali, or ultraviolet radiation so that all of the original properties are removed or diminished
NOTES:
Ak ostane cas – co presne je PCR?, denaturing high performance liquid chromatographynnPreco 2. mutacia ma take iste mnozstvo cal2? (aktivita je vyssia aj bez PKA)nMissense mutationnMedicolegalnZistit ake su statistiky teraz (SIDS – 1/1000?)
polymerase
an enzyme that catalyzes the formation of new DNA and RNA from an existing strand of DNA or RNA
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
postnatal
occurring immediately after birth
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal ???
substrate
the substance that is acted upon by an enzyme or ferment
NOTES:
To elicit..e.g iso elicited equal effects on heart ratesnTachycardia was induciblennThese findings siggest that this mutation in RyR2 enhances the susceptibility to arrhythmias in young mice and that the increased arrhythmogenic substrate in these mice might lead to the enhanced incidence of SIDS.
neonatal
relating to or affecting the infant during the first month after birth
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
preponderantly
much greater in number or influence
NOTES:
PrecedednPreponderantly nProspectivelynElectivelynProarrhythmogenicnSubsequentlynCo su ectopic beats?
de novo
from the beginning
NOTES:
Spontaneous germ line mutations (sporadic de novo )nnFamilial mutationsnConfer – udelit…these mutations confer a leaky phenotype on the channelnAberrantnnVELMI DOLEZITE – relationship between leak and arrhythmia – how?
elusiveness
the quality of being difficult to grasp or pin down
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
heritable
capable of being inherited
NOTES:
Compendium – suhrn, zoznam, prehladnHeritable – vyslovnost?
sequester
keep away from others
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequestered nTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
incidence
the relative frequency of occurrence of something
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidence nLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
syncope
(phonology) the loss of sounds from within a word (as in `fo'c'sle' for `forecastle')
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncope nEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
aberrant
markedly different from an accepted norm
NOTES:
Spontaneous germ line mutations (sporadic de novo)nnFamilial mutationsnConfer – udelit…these mutations confer a leaky phenotype on the channelnAberrant nnVELMI DOLEZITE – relationship between leak and arrhythmia – how?
susceptibility
the state of being susceptible; easily affected
NOTES:
Confounding effectsnSusceptibility nnArrhythmias in mice and patience with genetic mutations in RyR2 are almost always triggered by stress or catecholamines.
familial
relating to or having the characteristics of a family
NOTES:
Spontaneous germ line mutations (sporadic de novo)nnFamilial mutationsnConfer – udelit…these mutations confer a leaky phenotype on the channelnAberrantnnVELMI DOLEZITE – relationship between leak and arrhythmia – how?
putative
purported; commonly put forth or accepted as true on inconclusive grounds
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezacgytitel...
weaning
the act of substituting other food for the mother's milk in the diet of a child or young mammal
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaning nNeonatal versus postnatal???
precipitating
bringing on suddenly or abruptly
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
confer
present
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
elucidate
make clear and (more) comprehensible
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidate nSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
elusive
skillful at eluding capture
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
pursuant
(followed by `to') in conformance to or agreement with
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezacgytitel...
elicit
call forth (emotions, feelings, and responses)
NOTES:
To elicit ..e.g iso elicited equal effects on heart ratesnTachycardia was induciblennThese findings siggest that this mutation in RyR2 enhances the susceptibility to arrhythmias in young mice and that the increased arrhythmogenic substrate in these mice might lead to the enhanced incidence of SIDS.
auditory
of or relating to the process of hearing
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
compendium
a publication containing a variety of works
NOTES:
Compendium – suhrn, zoznam, prehladnHeritable – vyslovnost?
confounding
that confounds or contradicts or confuses
NOTES:
Confounding effectsnSusceptibilitynnArrhythmias in mice and patience with genetic mutations in RyR2 are almost always triggered by stress or catecholamines.
sporadic
recurring in scattered and irregular or unpredictable instances
NOTES:
Spontaneous germ line mutations (sporadic de novo)nnFamilial mutationsnConfer – udelit…these mutations confer a leaky phenotype on the channelnAberrantnnVELMI DOLEZITE – relationship between leak and arrhythmia – how?
inborn
normally existing at birth
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
sequestered
kept separate and secluded
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequestered nTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
sentinel
a person employed to keep watch for some anticipated event
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
perturbation
the act of causing disorder
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezacgytitel...
elicited
called forth from a latent or potential state by stimulation
NOTES:
To elicit..e.g iso elicited equal effects on heart ratesnTachycardia was induciblennThese findings siggest that this mutation in RyR2 enhances the susceptibility to arrhythmias in young mice and that the increased arrhythmogenic substrate in these mice might lead to the enhanced incidence of SIDS.
wean
gradually deprive (infants and young mammals) of mother's milk
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaning nNeonatal versus postnatal???
genetic
of or relating to the science of genetics
NOTES:
Confounding effectsnSusceptibilitynnArrhythmias in mice and patience with genetic mutations in RyR2 are almost always triggered by stress or catecholamines.
ostensibly
from appearances alone
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
enhanced
increased or intensified in value or beauty or quality
NOTES:
To elicit..e.g iso elicited equal effects on heart ratesnTachycardia was induciblennThese findings siggest that this mutation in RyR2 enhances the susceptibility to arrhythmias in young mice and that the increased arrhythmogenic substrate in these mice might lead to the enhanced incidence of SIDS.
precipitate
hurl or throw violently
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
conform to
behave in accordance or in agreement with
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform to nWeaningnNeonatal versus postnatal???
precede
be earlier in time; go back further
NOTES:
Preceded nPreponderantlynProspectivelynElectivelynProarrhythmogenicnSubsequentlynCo su ectopic beats?
conform
be similar, be in line with
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
beats
a United States youth subculture of the 1950s; rejected possessions or regular work or traditional dress; for communal living and psychedelic drugs and anarchism; favored modern forms of jazz (e.g., bebop)
NOTES:
PrecedednPreponderantlynProspectivelynElectivelynProarrhythmogenicnSubsequentlynCo su ectopic beats ?
germ
a small apparently simple structure (as a fertilized egg) from which new tissue can develop into a complete organism
NOTES:
Spontaneous germ line mutations (sporadic de novo)nnFamilial mutationsnConfer – udelit…these mutations confer a leaky phenotype on the channelnAberrantnnVELMI DOLEZITE – relationship between leak and arrhythmia – how?
prudent
careful and sensible; marked by sound judgment
NOTES:
Prudent – preziravy, rozvaznynnnnn
decisive
characterized by decision and firmness
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
sympathetic
expressing or feeling or resulting from sympathy or compassion or friendly fellow feelings; disposed toward
NOTES:
Exportnut zotero databazu na Amitov notebook!nnhypoxiannparasympathetic versus sympathetic tone?
subsequently
happening at a time subsequent to a reference time
NOTES:
PrecedednPreponderantlynProspectivelynElectivelynProarrhythmogenicnSubsequently nCo su ectopic beats?
reveal
make visible
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnReveal nVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
confound
be confusing or perplexing to; cause to be unable to think clearly
NOTES:
Confounding effectsnSusceptibilitynnArrhythmias in mice and patience with genetic mutations in RyR2 are almost always triggered by stress or catecholamines.
reverse
change to the contrary
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
induce
cause to do; cause to act in a specified manner
NOTES:
Increased incidence of SIDS in mutant mice might be caused by cardiac arrhythmias that are induced under conditions of catecholaminergic stress.
exertion
use of physical or mental energy; hard work
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
render
give or supply
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezacgytitel...
induced
brought about or caused; not spontaneous
NOTES:
Increased incidence of SIDS in mutant mice might be caused by cardiac arrhythmias that are induced under conditions of catecholaminergic stress.
reaction
an idea evoked by some experience
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reaction nConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
relationship
a relation between people; (`relationship' is often used where `relation' would serve, as in `the relationship between inflation and unemployment', but the preferred usage of `relationship' is for human relations or states of relatedness)
NOTES:
Spontaneous germ line mutations (sporadic de novo)nnFamilial mutationsnConfer – udelit…these mutations confer a leaky phenotype on the channelnAberrantnnVELMI DOLEZITE – relationship between leak and arrhythmia – how?
rates
a local tax on property (usually used in the plural)
NOTES:
To elicit..e.g iso elicited equal effects on heart rates nTachycardia was induciblennThese findings siggest that this mutation in RyR2 enhances the susceptibility to arrhythmias in young mice and that the increased arrhythmogenic substrate in these mice might lead to the enhanced incidence of SIDS.
link
connect, fasten, or put together two or more pieces
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal link nConform tonWeaningnNeonatal versus postnatal???
manifest
clearly revealed to the mind or the senses or judgment
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifest nExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
patience
good-natured tolerance of delay or incompetence
NOTES:
Confounding effectsnSusceptibilitynnArrhythmias in mice and patience with genetic mutations in RyR2 are almost always triggered by stress or catecholamines.
event
something that happens at a given place and time
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
fig
Mediterranean tree widely cultivated for its edible fruit
NOTES:
Opytat sa Anetty na ten fig .1 – nech mi to vysvetlinnWhere is cal2-binding domain?
error
a wrong action attributable to bad judgment or ignorance or inattention
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
performance
the act of performing; of doing something successfully; using knowledge as distinguished from merely possessing it
NOTES:
Ak ostane cas – co presne je PCR?, denaturing high performance liquid chromatographynnPreco 2. mutacia ma take iste mnozstvo cal2? (aktivita je vyssia aj bez PKA)nMissense mutationnMedicolegalnZistit ake su statistiky teraz (SIDS – 1/1000?)
pace
the relative speed of progress or change
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacing nReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
model
representation of something (sometimes on a smaller scale)
NOTES:
Gaburjakovej clanok o lum Ca – ako sa vola model flow through?
effect
a phenomenon that follows and is caused by some previous phenomenon
NOTES:
Confounding effects nSusceptibilitynnArrhythmias in mice and patience with genetic mutations in RyR2 are almost always triggered by stress or catecholamines.
chain
a series of (usually metal) rings or links fitted into one another to make a flexible ligament
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
cause
events that provide the generative force that is the origin of something
NOTES:
Increased incidence of SIDS in mutant mice might be caused by cardiac arrhythmias that are induced under conditions of catecholaminergic stress.
risk
a source of danger; a possibility of incurring loss or misfortune
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
remains
the dead body of a human being
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
flow
move along, of liquids
NOTES:
Gaburjakovej clanok o lum Ca – ako sa vola model flow through?
finding
something that is found
NOTES:
To elicit..e.g iso elicited equal effects on heart ratesnTachycardia was induciblennThese findings siggest that this mutation in RyR2 enhances the susceptibility to arrhythmias in young mice and that the increased arrhythmogenic substrate in these mice might lead to the enhanced incidence of SIDS.
surface
the outer boundary of an artifact or a material layer constituting or resembling such a boundary
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
conditions
the prevailing context that influences the performance or the outcome of a process
NOTES:
Increased incidence of SIDS in mutant mice might be caused by cardiac arrhythmias that are induced under conditions of catecholaminergic stress.
equal
having the same quantity, value, or measure as another
NOTES:
To elicit..e.g iso elicited equal effects on heart ratesnTachycardia was induciblennThese findings siggest that this mutation in RyR2 enhances the susceptibility to arrhythmias in young mice and that the increased arrhythmogenic substrate in these mice might lead to the enhanced incidence of SIDS.
evidence
your basis for belief or disbelief; knowledge on which to base belief
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
presence
the state of being present; current existence
NOTES:
SLOVICKA:nXander, 2009nnProspectively – nCo presne znamena heterozygousnIncidencenLittermatesnRevealnVentricular ectopynSurface ecgnIntracardiac pacingnReverse transcription-polymerase chain reactionnConfer – mutation confers an increased risk of cardiac arrhythmianElucidatenSequesterednTachycardianSyncopenEctopicnRevealed the presence ofnCausal linknConform tonWeaningnNeonatal versus postnatal???
establish
set up or found
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
bind
secure with or as if with ropes
NOTES:
Opytat sa Anetty na ten fig.1 – nech mi to vysvetlinnWhere is cal2-binding domain?
tone
(music) the distinctive property of a complex sound (a voice or noise or musical sound)
NOTES:
Exportnut zotero databazu na Amitov notebook!nnhypoxiannparasympathetic versus sympathetic tone ?
beat
hit repeatedly
NOTES:
PrecedednPreponderantlynProspectivelynElectivelynProarrhythmogenicnSubsequentlynCo su ectopic beats ?
rate
a quantity or amount or measure considered as a proportion of another quantity or amount or measure
NOTES:
To elicit..e.g iso elicited equal effects on heart rates nTachycardia was induciblennThese findings siggest that this mutation in RyR2 enhances the susceptibility to arrhythmias in young mice and that the increased arrhythmogenic substrate in these mice might lead to the enhanced incidence of SIDS.
condition
a mode of being or form of existence of a person or thing
NOTES:
Increased incidence of SIDS in mutant mice might be caused by cardiac arrhythmias that are induced under conditions of catecholaminergic stress.
might
physical strength
NOTES:
Increased incidence of SIDS in mutant mice might be caused by cardiac arrhythmias that are induced under conditions of catecholaminergic stress.
position
the particular portion of space occupied by something
NOTES:
Prone position nInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
lead
take somebody somewhere
NOTES:
To elicit..e.g iso elicited equal effects on heart ratesnTachycardia was induciblennThese findings siggest that this mutation in RyR2 enhances the susceptibility to arrhythmias in young mice and that the increased arrhythmogenic substrate in these mice might lead to the enhanced incidence of SIDS.
ten
the cardinal number that is the sum of nine and one; the base of the decimal system
NOTES:
Opytat sa Anetty na ten fig.1 – nech mi to vysvetlinnWhere is cal2-binding domain?
death
the permanent end of all life functions in an organism or part of an organism
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezacgytitel...
remain
continue in a place, position, or situation
NOTES:
Prone positionnInborn errors of metabolismnDecisive – rozhodujuci, presvedcivynElusive – tazko zachytitelne priciny, tazko postihnutelnennZase conferring – evidence establishing LQTS-conferring cardiac channel mutations as the ….or mechanism remains elusive (ja)nnPrecipitating event – vyvolavajuca udalostnnAuditory stimuli – sluchovy podnetnManifestnExertion – namahanSentinel event, sentinel = hliadka, straz, strazcanOstensibly – zdanlivo, udajnenElusiveness – nepostihnutelnost, nezac...
line
a length (straight or curved) without breadth or thickness; the trace of a moving point
NOTES:
Spontaneous germ line mutations (sporadic de novo)nnFamilial mutationsnConfer – udelit…these mutations confer a leaky phenotype on the channelnAberrantnnVELMI DOLEZITE – relationship between leak and arrhythmia – how?
almost
(of actions or states) slightly short of or not quite accomplished; all but
NOTES:
Confounding effectsnSusceptibilitynnArrhythmias in mice and patience with genetic mutations in RyR2 are almost always triggered by stress or catecholamines.