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- Santa the legendary patron saint of children
- Santee a member of the eastern branch of the Sioux
- sandhi the articulatory process whereby the pronunciation of a word or morpheme changes when it is followed immediately by another (especially in fluent speech)
- sanity normal or sound powers of mind
- saint a person who has died and has been declared a saint by canonization
- sandy resembling or containing or abounding in sand
- sand a loose material consisting of grains of rock or coral
- Santa Ana Mexican general who tried to crush the Texas revolt and who lost battles to Winfield Scott and Zachary Taylor in the Mexican War (1795-1876)
- Sand French writer known for works concerning women's rights and independence (1804-1876)
- Santa Fe capital of the state of New Mexico
- Santa Anna Mexican general who tried to crush the Texas revolt and who lost battles to Winfield Scott and Zachary Taylor in the Mexican War (1795-1876)
- sanative tending to cure or restore to health
- sanitary free from filth and pathogens
- sanitate provide with sanitary facilities or appliances
- Sana'a the capital and largest city of Yemen
- sandal a shoe consisting of a sole fastened by straps to the foot
- suntan a browning of the skin resulting from exposure to the rays of the sun
- Zantac a histamine blocker and antacid (trade name Zantac) used to treat peptic ulcers and gastritis and esophageal reflux
- Santos a port city in southwestern Brazil on an offshore island near Sao Paulo
- Sontag United States writer (born in 1933)