If you've ever become so frustrated with someone or something that you feel like you're at the end of your rope, you have experienced exasperation. You are fed up!
Exasperation goes back to the Latin verb exasperare, meaning “to make rough.” When you are in a state of exasperation, you feel like something annoying you've had to put up with has put you in a rough mood. If you take up golf, you might find it to be a source of relaxation or a source of exasperation. Watching you try to teach your dog to fetch, I'm not sure which is more amusing: his stubbornness or your exasperation.