A predilection is a preference for or bias toward something. If you have a predilection for wool clothing, you should take up knitting.
Predilection is based on the Latin verb praediligere, or to choose in advance, which breaks down to prae, in advance, and diligere, select. We often use predilection for tendencies that people seem to have been born with, also called predispositions. If you're a night owl, you probably have a predilection for cities, while morning people tend to prefer the country.